Citing and Reading Behaviours in High-Energy Physics. How a Community Stopped Worrying about Journals and Learned to Love Repositories

Contemporary scholarly discourse follows many alternative routes in addition to the three-century old tradition of publication in peer-reviewed journals. The field of High- Energy Physics (HEP) has explored alternative communication strategies for decades, initially via the mass mailing of paper copies of preliminary manuscripts, then via the inception of the first online repositories and digital libraries. This field is uniquely placed to answer recurrent questions raised by the current trends in scholarly communication: is there an advantage for scientists to make their work available through repositories, often in preliminary form? Is there an advantage to publishing in Open Access journals? Do scientists still read journals or do they use digital repositories? The analysis of citation data demonstrates that free and immediate online dissemination of preprints creates an immense citation advantage in HEP, whereas publication in Open Access journals presents no discernible advantage. In addition, the analysis of clickstreams in the leading digital library of the field shows that HEP scientists seldom read journals, preferring preprints instead.Comment: Version to be published in Scientometric

Signal to background

Breathable foam for fire prevention; swords to plowshares; naming LHC magnets; more than 4000 LHC-related papers in spires database; Fermilab’s remote operations center; LHC summer schools at Fermilab and SLAC

From Autocracy to Democracy: The Effort to Establish Market Democracies in Iraq and Afghanistan Conference

The conference focused the legal, political, economic, and security issues facing post-war Iraq and Afghanistan

Consumer palatability scores and volatile beef flavor compounds of five USDA quality grades and four muscles

Proximate data, consumer palatability scores and volatile compounds were investigated for four beef muscles (Longissimus lumborum, Psoas major, Semimembranosus and Gluteus medius) and five USDA quality grades (Prime, Upper 2/3 Choice, Low Choice, Select, and Standard). Quality grade did not directly affect consumer scores or volatiles but interactions (P < 0.05) between muscle and grade were determined. Consumer scores and volatiles differed (P < 0.05) between muscles. Consumers scored Psoas major highest for tenderness, juiciness, flavor liking and overall liking, followed by Longissimus lumborum, Gluteus medius, and Semimembranosus (P < 0.05). Principal component analysis revealed clustering of compound classes, formed by related mechanisms. Volatile n-aldehydes were inversely related to percent fat. Increases in lipid oxidation compounds were associated with Gluteus medius and Semimembranosus, while greater quantities of sulfur-containing compounds were associated with Psoas major. Relationships between palatability scores and volatile compound classes suggest that differences in the pattern of volatile compounds may play a valuable role in explaining consumer liking

Seeds of Resilience: Learning from COVID-19 to Strengthen Seed Systems in Vermont

Seeds are central to crop-based production systems, yet in the United States seeds have been largely overlooked in both research and local and regional food systems initiatives. This report seeks to address the gap in seed-related research by assessing current strengths and vulnerabilities of Vermont’s seed systems. In particular, the findings presented in this report illuminate how seed systems can maintain function in the face of external shocks such as the COVID-19 pandemic, and how we can apply the lessons learned toward building resilience for an uncertain future due to factors such as climate change. Despite the turmoil caused by the pandemic, the last several years have provided a unique opportunity to identify strategies to strengthen Vermont’s seed systems. The data presented and discussed in this report build on existing research and showcase a myriad of seed-related efforts in Vermont. We use an interdisciplinary approach to study the supply and demand for seed among farmers and gardeners in Vermont during the COVID-19 pandemic. To contextualize our report, we begin with a brief summary of findings taken from the 2020 and 2021 Vermonter Polls regarding seed system trends. Data from these surveys, conducted by the UVM Center for Rural Studies, were collected in February-March 2020 (before and during the onset of the pandemic in Vermont) and February- March 2021 (nearly a year into the pandemic). We then present the findings from two online surveys of commercial farmers (n=73) and non-commercial seed growers (n=75) in Vermont, which include a specific focus on five commonly grown crops in Vermont: garlic, tomatoes, squash, lettuce, and potatoes. In the future, this work can guide collaborative and participatory responses to seed system vulnerabilities exposed by the COVID-19 crisis

Identifying related cancer types based on their incidence among people with multiple cancers

BACKGROUND: There are several reasons that someone might be diagnosed with more than one primary cancer. The aim of this analysis was to determine combinations of cancer types that occur more often than expected. The expected values in previous analyses are based on age-and-gender-adjusted risks in the population. However, if cancer in people with multiple primaries is somehow different than cancer in people with a single primary, then the expected numbers should not be based on all diagnoses in the population. METHODS: In people with two or more cancer types, the probability that a specific type is diagnosed was determined as the number of diagnoses for that cancer type divided by the total number of cancer diagnoses. If two types of cancer occur independently of one another, then the probability that someone will develop both cancers by chance is the product of the individual probabilities for each type. The expected number of people with both cancers is the number of people at risk multiplied by the separate probabilities for each cancer. We performed the analysis on records of cancer diagnoses in British Columbia, Canada between 1970 and 2004. RESULTS: There were 28,159 people with records of multiple primary cancers between 1970 and 2004, including 1,492 people with between three and seven diagnoses. Among both men and women, the combinations of esophageal cancer with melanoma, and kidney cancer with oral cancer, are observed more than twice as often as expected. CONCLUSION: Our analysis suggests there are several pairs of primary cancers that might be related by a shared etiological factor. We think that our method is more appropriate than others when multiple diagnoses of primary cancer are unlikely to be the result of therapeutic or diagnostic procedures

CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence

The recognition of human leukocyte antigen (HLA)-E by the heterodimeric CD94-NKG2 natural killer (NK) receptor family is a central innate mechanism by which NK cells monitor the expression of other HLA molecules, yet the structural basis of this highly specific interaction is unclear. Here, we describe the crystal structure of CD94-NKG2A in complex with HLA-E bound to a peptide derived from the leader sequence of HLA-G. The CD94 subunit dominated the interaction with HLA-E, whereas the NKG2A subunit was more peripheral to the interface. Moreover, the invariant CD94 subunit dominated the peptide-mediated contacts, albeit with poor surface and chemical complementarity. This unusual binding mode was consistent with mutagenesis data at the CD94-NKG2A–HLA-E interface. There were few conformational changes in either CD94-NKG2A or HLA-E upon ligation, and such a “lock and key” interaction is typical of innate receptor–ligand interactions. Nevertheless, the structure also provided insight into how this interaction can be modulated by subtle changes in the peptide ligand or by the pairing of CD94 with other members of the NKG2 family. Differences in the docking strategies used by the NKG2D and CD94-NKG2A receptors provided a basis for understanding the promiscuous nature of ligand recognition by NKG2D compared with the fidelity of the CD94-NKG2 receptors